Sounds like some pretty cool guitars you people have listed but for me, out of the six different guitars I own, my 1979 (one owner) Fender Stratocaster is my favorite. The only modification done was I pulled out the stock Fender pickups and replaced them with Seymour Duncans probably within the first week that I bought the guitar. But a lot depends on your particular style of playing. Since I play a heavy blues (SRV, Hendrix) style , the Strat is the axe for me. However, I own a 62 cherry sunburst Gibson LP (which is too damn heavy) and does have a sweet warm response. I generally use it when I'm doing Classic Rock stuff.
I've never owned a PRS however I do play Jazz Fusion and I think that would most likely be a better guitar for Fusion than my Strat is.