Version 2.0 would only work with the Syntrillium Red Rover. V2.1 added capability for the US428, Mackie Universal Control etc.
You should be able to use the US428 to route the signal, although the transport functions won't work. Just select both the soundcard and the US428 in the Options/Device Order and then select which port you want to use for each track when you set up the session.