Seeker of Rock
The One and Only
Hey OP: I have heard some pretty convincing amp simulators (so I'm told they were) through my shitty computer monitors when listening to online compressed computer files. I think it has been said already while skimming through here and I'll reiterate: your playing and song and music is generally what your target audience is going to hear the most. Only audiophiles with setups way better than my little analog chain are going to dispute you if you get it sounding good. But personally, I like the analog way because it works and feels best to me. But I could rock some guitar for you through a Pod and make it sound good just as easily as through my amps.
I should clarify that the context of this was for home recording. I don't think any real studios are selling their vintage amps in lieu of plug-ins and sims and I know I sure as hell am not. But for goofing around or creating demo recordings, I think sims do fine.