Plug yer amp's line out to line in. Plug yer guitars into guitar in.
Pickups and microphones have very low output, thus preamps have special inputs for them. Active pickups are still low level even though they are amplified themselves because they still have to plug into guitar inputs on things like guitar amps and stompboxes.
Any other gear is high level, labeled -10 dbv ('consumer gear') and +4 dbv ('pro' gear), except headphone outputs (iPods, cell phones, portable players) which are even higher level (turn the device's volume down low or use an attenuating patch chord to lower the signal before plugging into a preamp). Tape decks, mixers, component cd & dvd players, FM tuners, effects units (reverbs & delays), compressors, - anything labeled "line out" goes to the input labeled "line in".
Also, power amp outs go into speakers, passive crossovers, attenuators, dummy loads, antennas, or linear amplifiers (never into a preamp or a line/mic/guitar in!). Another danger is a high voltage line driver (used in old PA systems, churches and halls) usually there's a transformer at each end of the line - just run away if you encounter this or seek professional assistance.
SPDIF and AES/EBU on RCA or coaxial connectors along with ADAT & TOS-Link on optical connectors are digital and not analog audio and don't connect to anything other than themselves.
Hope this answers yer question (probably too much info but I can't help it - Gemini w/ Virgo rising, AADD and Mtn Dew!).
And when it comes up, search here for the scoop on balanced v.s. unbalanced inputs and outputs, hi and lo-z microphones, butter or margarine, etc. Good luck and Enjoy!