Buss noise, is a frequent problem on USB powered audio devices. You can buy inline USB monitors, that show how many volts are present on the USB input, and as the current demand increases, the voltage drops, sometimes pretty pathetically - the computer just cannot provide the current a USB device needs. USB1 and 2 are supposed to be able to provide 500mA, and USB3 connectors increase that to 900mA, but as anyone who uses USB chargers knows too well - not all USB sockets can actually provide this. Once the voltage drops, problems creep in. My friend had this with his 2i2 devices, and it looks like Presonus devices are the same.
Using a USB hub to provide the power instead of the computer often works great - as does using a USB3 socket if available. The nasty data noises that creep in can be surprisingly easy to fix, for very little money - and most times it's the computer, not the interface that is to blame.