Well, not really. First off, we'll assume the speakers are correctly wired, and not out of phase, which will certainly color the sound.
But if you replace a single mono speaker with dual mono speakers, the multiple source points overlap at different factors of wavelength, causing constructive and destructive interference. Human hearing covers wavelengths from about 2cm to well over 15m. Speakers three feet across will exhibit different tonal characteristics from earbuds about 18cm apart, and both will be different from speakers that are any other distance apart.
But really, once you're getting into that critical a difference, it's going to be pointless to bother. Different listeners will be listening through different speakers or earbuds altogether.
My Shure consumer ear buds will sound very different from my Sennheiser reference headphones.
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