The Subtractor is a computer simulation of an analog sound module AKA a synthesizer. It doesn't play samples or loops because that not it's purpose.
If you advance beyond using samples and loops, you may find a need at some point to compose a bass line or a melodic solo --- that is what the Subtractor excels at. Which is not to say it's any slouch in the atmospherics, strings or pads departments...
Actually I use Cubase SX2 (thanx to Santa a.k.a my wife). But every once in awhile I'll dig out FlStudio 4 (Nephew gave me that one free, cause he got it as a gift, and couldn't stand the whole pattern based thing). Occassionally I'll dig out my Reason Adapted or go to my cousins and use his Reason 2.5.
Reason just seems limited in too many ways for the way I work. FLStudio is a blast though