Here's what I think he means:
At one point in time, a band called Quiet Riot had the number 1 selling record in America. Now consider that Pink Floyd's "Dark Side of the Moon" never hit #1 on the charts. One of these records continues to sell and to bring in a steady income stream large enough so that the band members will be rich for the rest of their (and their future generations') lives. The other is still kind of a running joke, and might still be playing the Dokken or "Great White" circuit.
I believe that if you want to be the next Quiet Riot, then do what everyone else is doing. Layer on the cheesy drum samples and whatever else you want to do to your heart's content. On the other hand, if you want to be the next Pink Floyd, the Who, Led Zep, etc. ... then just be true to your music and your sound.
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