Yes, it works. 
I have the Core 40 USB'ed into my desktop Asus and it shows up in Samplitude SE8*. Obviously you could run other tracks in Sam or a VSTi. 
The attached grab shows a decent -60dB noise floor from  Tele twisled round for min hum. At that setting my (few bars!) of Bach gave a neg 20ish level. 
Note, the level from USB depends upon the levels set on the amp. I had gain at 2o/c and vol at 1o/c . This gave a reasonable volume in the room but if you wanted to record in the wee smalls, plug in cans. You might be able to change the acoustic/USB  balance in Windows pr/and in the Insider s/ware. I shall ask since I have other issues to discuss with B's about the Core. 
*Now! In Sam you can use more than one USB interface at a time using MME drivers. I shall give this a go with my laptop and the KA6. But busy atmo so don't whittle! 
Dave.