Welcome aboard, midwest.
Yes and no. I believe the control surface of the 428 can be set up to control Pro Tools, but it audio part of it will never work. The MIDI i/o works, too.
If you don't know already, to use Pro Tools LE you have to have of the the Pro Tools interfaces: mBox, 002 rack or 002. No way around it, unfortunately. There is a version of Pro Tools (Pro Tool M-Powered) that works with many of the M-audio interfaces these days, too.
Take care,
Chris