I've been using Nuendo for a few months now.  Very impressed with it.  I used Cubase VST for a year before and the main advantages Nuendo has over Cubase (at least the version I was using VST 3.7)
- Unlimited Undo's
- Better integrated editing features.
- Loads of right click funtionality
- Automation better implemented.
- The audio pool actually works.  Very easy to keep track of data that is not in use, and zap it in one easy step freeing up hard drive space.
- Managing tracks and groups very customizable.
Many other features I'm skimming the surface here.  Little things like - when you give a track a name in the arrange window, it also names the fader on the mixer etc.
IMO it's the best software multitracker out there.
Don't know what 
Northpole is...