i'm working with MACKIE 24/8bus and had opportunity to work with GHOST, and i have to say that GHOST is better choice (for live performance) , cause it has more aux outputs wich is really great when you don't have monitor mix pult. For example, i use four separate monitor lines, and Mackie has only 4 aux outputs that can use in the same time, but i use aux for reverb to, and then have to use tips and tricks with MIX B. So, for Live GHOST is better choice..
For studio, MACKIE is great, and cheaper, and I realy enjoy to work with them