The opamps (Burr Brown 2604-DigiKey) and tubes (any better 7025 tube) are socketed, so you just pull one out and put a new one in.
The transformer (Cinemag CMMI-8B3, Lundahl LL1538, or Jensen JT-110K-HPC-order from their websites) switch is a bit more complicated, but no too much so. You'll need to desolder the old ones, and then possibly add a zobel network across the secondaries of the new one (I know you have to on the Cinemags-see the data sheet at Cinemag.com). The Cinemag doesn't screw into the old holes, so I glued them to the board with silicone.
There are also capacitor, resistor and pot upgrades, but I only did what is listed above because I liked the sound with those three changes.