Almost stayed out of this one, but...
The Express series are my least favorite Mesas I've ever played, especially compared to the (excellent) F-series they replace. That said, your description above is about the one playing situation I'd recommend them for.
I'd still see if you couldn't find a used F-30, as honestly that's one of the nicer cleans I've ever heard. Likewise, if you're going to drop the cash for a Mesa and you're into blues/rock, you owe it to yourself to check out the Lone Star series. The Lone Stars are some of the creamiest, smoothest, spongiest sounding amps I've ever played, and I suspect would be positively orgasmic with a tele. The Express, meanwhile, are a bit grungier, darker, and crunchier. I could see them handling singlecoils well, and if you're looking for a raw, grungy, grindy sort of blues-blues/rock sound they could qork quite well.
So, give it a shot, there's a 50-50 chance it might work out well for you. But also be sure to A/B it with a Lone Star Special, given your wants.