Speaker ratings aren't like light bulb ratings, because a power amp doesn't provide a standard voltage. Thus a speaker rating doesn't mean that it will consume 150W, it means that is the max you should drive it.
If you hook one 4 ohm speaker into one side of your amp, then the max power output of the amp is 250W. That of course could be a bad thing for your speaker, since that exceeds its rating of 150W.
With two 8 ohms speakers in parallel into one side, they each could be powered to 125W, again a bad thing for 50W speakers
So with that setup, you'd have to be sure not to crank the power amp too much.
With two sides of 12 ohms total, your speakers are safe; although your amp isn't working at capacity, you don't want it to with the cabs you have. However you will need to wire your cabinets to work in series.
Farview is correct in that there's no way to really balance this. If you balance the impedance on both sides of the amp, then the amp is as happy as possible, but with cabs of different impedance, the volume at each speaker will vary (not only with power but also the sensitivity of the driver itself). This is why one usually tries to get identical cabinets with the same impedance, often 8 or 16 ohms, which enables you to use a lot of cabinets without dropping below a single amp's impedance rating.