ahhhh,
The Blue Tubes will definately change the tone when you drive them hotter.
In that case go with what sounds best to you. I dont have those so cant tell you the settings to use. Tube preamps and compressors are used because people want to add that tone to a bass, guitar or vocals.
As you are learning the tube tone isnt always desirable. That is where a non tube preamp can be more desirable for a more transparent tone.
Or just use the minimum amount of gain into the preamp before the tube really starts warming it up. Dont use the compression for tracking unless you really want or need to.