Get the right ones, learn how to use them, re-amp into a good cab to mic, or find some great cab impulses to keep it all in software. Nobody will know the difference if done right. I use them for guitar all the time, as I don't have my own guitar amp. Primarily a bassist, so all my money went into my bass amp right away. =P I'd say if you can afford it, get a good amp though. I feel like I play a lot differently through an amp compared to plugging direct. I feel more like I'm performing it, than just getting some sound into the computer.