Depends partly on how good your amp is. There is a very real threat from flyback voltage if the impedance mismatch is too great. Cheap amps can get zapped by it, good amps can mostly handle it.....but it's not worth the risk. I would never mismatch more than 1 level. I would mismatch a 4 ohm amp out to an 8 ohm speaker, but not to a 16 ohm speaker.
I have never seen an amp with a 2 ohm output. I don't understand why they would design it that way, other than to maximize power and current and minimize tube life. For one thing, you could never get a proper match with just one speaker, as nobody that I know of makes a 2 ohm speaker.