well, first off...don't plug a microphone into the speaker. I'm not sure why Shambler brought that up.
secondly, the manufacturer just gave you multiple options to choose from for connecting to that speaker. the top is for unbalanced RCA connections and the bottom one is for balanced XLR or TRS connectors. Depending on what you are plugging into it determines which connection you use. But try and use the balanced connections if you can.