Yeah, I've used an M-Audio Ozone (which is a small USB MIDI keyboard + audio interface) and the Lexicon Omega with Home Studio. You're unlikely to find an interface at a reputable music store (like zzounds.com, americanmusical.com, sweetwater.com) that WON'T work with Home Studio.
You might as well look around, find an interface you think you want, and then check here to make sure there aren't any known problems with it. In short, compatability issues are the exception, not the rule.