I guess I'm all for experimenting... but I remember back in the day doing a TON of reading about this on the internet, particularly in the context of metal production, and going through a phase where I sidechained my bass off my kick on eveything... And it's probably been a solid decade since I've bothered to set up a sidechain on anything now. Actually, that's a lie, did it for a video a while back where I had two mics running, one to talk into, and a second on my acoustic guitar, and I used a sidechain to absolutely busy the vocal mic whenever I so much a strummed a chord on the acoustic, and then trimmed thge acoustic mic to JUST the sections where I was playing, to effectively zero out bleed from the "speech" mic into the recording.
But, it's stuff like that, really, these days. I spend a lot more time on just getting the balance between the two right so they fit together in the mix without having to do anything dynamic to get them to gel, and that would be sort of a last resort.