I have an Audiophile 2496 PCI card as well (in addition to my Delta 1010).
You need a mic preamp to amplify the mic's signal (this will run from the XLR out of the mic into the XLR into the preamp). Then, assuming the preamp has 1/4in outputs, you will need a 1/4" to RCA cable (or cable with adapters) to connect the preamp output to the RCA input on the 2496 card. If the preamp only has XLR outputs, you will need an XLR to RCA cable (or cable with adapters).
The 2496 has 2 inputs and 2 outputs. You could hook up 2 channels of mics to the inputs.
For the monitors, you will hook them up to the outputs on the 2496 card. You will need appropriate RCA to XLR (or 1/4") cables for that.
cheers,
wade