I don't think there is such a thing as a typical home studio setup. You just use the gear in a way that works for you.
Having said that, you are asking the wrong questions. You shouldn't ask how can I make it work with the 3500. You should ask yourself what do you want to achieve, or what do you want to change and what are the tools that can help me with it.
The M-3500 is a nice console but it is BIG and I really don't see how it would fit into your work process. It mixes audio, it does NOT send fader positioning information to your DAW. As I wrote earlier, if you want to mix with the console, you'd need one or a few audio interfaces with basically as much channels as you have tracks. Then you can mix with the console. Every channel needs to be connected from the console to the computer for tracking and from the computer to the console back. Depending on your tracks that might be a lot of cabling but the M-3500 can do that because it's an inline console. But honestly, I don't see how you're going to integrate that into your setup. I think you need to ask yourself what you want to achieve. Ride faders, then go with the interface and it will cost you 1000 bucks tops.
If you buy a console, then you also need to buy a few multichannel audio interfaces (e.g. 8 channel interfaces from MOTU, Presonus or M-Audio, Tascam) if you want to track to your PC. Then on mixdown you can use the inserts on those cubase channels for effects (e.g. EQ, compression) and use the console for mixing and panning. But you need some outboard gear for bus fx or main fx or you need to go into your pc again (more channels and interface cards, one per fx channel) and you loose quality every time you do the analog-digital-analog conversion. That way you'd put more stress on your PC just because you're using it as an effects processor in addition to tracking. Finally you need to record the mixed signal either with a standalone recorder or into your PC again. I think with the console, interfaces, mediocre outboard gear for e.g. compression, reverb, limiting, you're looking at about 5.000 to 15.000 bucks already for a 16 channel setup. I don't think it's feasible. Apart from that, the console is not brand new so it might need to be fixed or maintained. It's ok if you can do that yourself but otherwise you're going to pay top dollar for that, too. I'd just buy some fader interface and the US-2400 is a nice unit. It all depends on what you want to do. What's your budget anyway?
Cheers
Tim