I run 'the best of both worlds' as it were... 2480DVD for all tracking and basic mixing/mastering... Sonar 7.02/Wavelab for 'in the trenches' mixing/mastering duties...
The 2480 is solid as a rock when recording 12 drum tracks, 2 guitars, bass and keys simultaneously... Sonar, running on a Dual Xeon 3.06/XP Pro/3 gigs Ram, can't even come close to the stability I get with my Roland