Good call on the TB. Not such a problem if you're going to an "Instrument" input, but you will want a buffer going into a line input.
Anyway, the OP has said a couple times that he plans to use an amp sim. That was the assumption that I've been running with. I will note, though, that "fizzy" is not always What you get when listening without cabinet filtration. Distortion/overdrive/fuzz might sound fizzy. Other pedals might just be really bright, or brittle, or "piezo-like". These sounds can be appropriate in places. With distortion or fuzz you might get Revolution #9, or NiN. With chorus you might get that 80s pop sound. But yeah, most of the time you'll want to put a cab sim on there.
Yeah, I think I do remember you saying that you don't actually have the pedals to "just fucking plug in and try it". Sorry about that. If you're trying to decide whether or not to get some, the answer is easy: Yes! Unless you're going for some fancy
boutique bullshit, it really isn't a huge investment to grab a couple of things, and you will find uses for them. Heck, you might even take advantage of some of the more liberal return policies from MF or the like. Buy a couple pedals and play with them for a couple weeks. If you don't like it enough to keep, just send it back.
I guess that I never actually gave my opinion on the matter. Gave some facts and discussed the practicalities, but never actually said which I think sound better, or prefer in general. TBH, all other issues set aside, I guess I would prefer to use my pedals over their ITB counterparts. I am fully aware that part of the reason is irrational fetishism

, but I do think they tend to sound better in some undefinable way.
That saidhere are some other practical points that have occurred to me:
1- The pedal version of an effect will always be noisier than it's ITB counterpart. Maybe not enough noisier to ruin a track, but measurably noisier. Something to consider especially if you're heading for
a high gain in the amp sim.
B- Host sync. If, for whatever reason, you want or need your delays and/or modulation effects to follow precisely on the beat throughout the entire song, you will definitely find it easier (and/or cheaper) to do it ITB. You can try to dial things in by hand and ear, but that's kind of a bitch. Tap tempo is cool, but it's only as accurate as the foot doing the tapping. Frankly, having things slightly out of sync can sound more natural and organic most of the time. I'm absolutely not saying that everything had to be locked to the grid. There are times, though, when you might want it, and trying to get it with pedals will turn you grey pretty quick.
III - Automation. Sure, you can turn pedals on and off by foot, but how many can you step on at one time? You can control the sweep of a wah pedal with your foot, but what if you want to change delay time while playing, or chorus depth, or...
Again, these points are not really trying to advocate anything. You need to consider how important these concerns are, perhaps even on a track-by-track basis. Then go buy some pedals anyway, because they're cool!