Not to muddy the water, but I have not seen a single vote for my all-time fav...Record/Reason from propellerhead. Go to propellerhead.se and download the free trial. You'll be amazed at the flexibility, etc. The price is higher, and honestly, I may be looking at reaper, because so many tout it's wonders. But, Record works the way a musician thinks. You can flip the rack around and rewire your plugins like a real rack. You can do everything from recording to mix to master. There are literally THOUSANDS of instruments/voices, and literally THOUSANDS of plug-ins available. Many are free. You can record from your gear, or add to the sound post. It has a Line6 guitar and bass add-in for amp/cab simulation. It can do vocoder (in some cool and interesting ways.) There are hundreds of recording tips/tutorial videos...
As has been said before...get under the hood. If you have no time to test drive a few, stick with one you know and run with it. But you never know.