I have the Delta 66 OMNI working with Logic Audio Platinum v. 5.5.
Here are the settings I have for doing exactly what you are trying to do..
Open up the Delta 66 control pannel and I will flip through the tabs with you...
(Forget about the Monitor mixer tab for the moment)
Patchbay / Router:
H/W Out 1/2: Monitor Mixer
H/W Out 3/4: H/W In 3/4
H/W Out x/x: BLANK
H/W Out x/x: BLANK
H/W Out S/PDIF: WaveOut S/PDIF
Hardware Settings:
Master Clock: Internal Xtal
Codec Sample Rate: Whichever you want to record at ( I record at 48,000
Tick off "Reset when Idle"
Multi-Track Driver Devices: Single and in Sync
Variable Signal Levels: +4 (for all 5 of them)
DMA Buffer Sizes: This all depends on your PC/Mac. Experiment until you have as little latency as possible.
S/PDIF:
Consumer
About:
Just information (Make sure you have the must up to date drivers.