No- The preamp line out plugs into the line in of the soundcard. There are some specialized preamps designed for USB output, including some fairly inexpensive ones (M-Audio MobilePre for one- $149). However, I think for general recording, most would agree that a soundcard designed to accept a variety of line inputs is more generally versatile, and will be a better choice going forward. If you really want to avoid the soundcard, firewire is the current choice for going direct to the hard drive. As far as recording the stuff you want to, the biggest change will be when you get the right MICROPHONE in front of your acoustic or guitar amp, and you STOP plugging the damn guitar directly into the recorder. A real vocal mic would help a lot too. It's simply a matter of what you choose to spend. At your level, moderate amounts of investment will produce big improvements. You need a soundcard, a preamp, a mic, and as soon as possible, monitors, so you can actually hear the unbiased version of what you did.-Richie