My first DAW set-up was Cubase SX 1.0 with Reason 1, I chained 4 M-Audio Delta 66's as interfaces (I needed external pre-amps for power which complicated things big time). I up graded both Cubase and Reason right up to version 3. It worked ok for me
The most recent system that I put together is Cubase 5 - with all updates - Native Instruments,
Komplete 6/
Kore 2 and 2 Steinberg,
MR816 CSX interfaces.
I am no-longer a properhead/m-audio guy, I am now a Steinberg/Cubase/NI guy from here on out. IMO a much better complement and much smoother work flow.
All I can say is it was worth the money and I am glad I went this route. A feature of the MR816's is that you can ADAT hook up a pre-amp through it as well as have 3 MR816's chained up. So, that's basically a 48 powered in's capacity (assuming your ADAT, Optical I/O pre-amps have 8 in's with 3 MR816's chained up).
The MR816 is plug and play, no messin with external pre-amp or mixing boards of any sort.
I have read that some people are having driver issues, but I am not. I record at 48 kHz 32 bit floating wav format and have not yet run out of room. I am currently working on a project with 54 tracks and most have 4-5 inserts as well as a couple sends to group and FX channels.
(EDIT: I should mention, no latency)
Also, the MR816 can be used as a mixing consul instead of a mixing board/amp setup - as a side note, with i7 processors now in laptops, I don't understand why anybody would use the MR816's stand alone.