Lets say you have a 64 channel or something mixer of that size and you want to use nuendo with it. That the best breakout box/sound that will do the trick?
Take a look at RME hardware (MADI stuff) or multiple motu 2408 MKIII on 424 pci card. That will only be the interfaces to get stuff into nuendo, you will still need the A/D's...ouch...