You may get better results posting this in the Guitar section
Typically Humbuckers are more geared towards straight out metal, where as single coils typically lend themselves to bluesy/cleaner sounds.
My personal favorite is H/S/S - (Seymour Duncan PA-TB2b in the Bridge! Great metal tone!!

)
But I tend to play a lot of bluesy/clean stuff as well......that's where the singles come in handy.
there are a lot of other factors invlolved with "Guitar Tone" as well. Such as: Body wood, neck wood, fretboard wood, Bridge type (Fixed or floating), nut material/type, fret wire, pots/wiring, paint/finish, pickups, cords/cables, effects, and amp.
Some of these are major, and some are very minor, but they all have an effect on the overall sound and tone of an electric guitar...............Are you confused yet?
Rick