I'm with mixmkr. While mixing with headphone has obvious problems, there are some real advantages too. First and foremost is the fact that most people on this board don't have very good listening environments. Not only are there frequency related problems in most of our rooms (standing waves, etc), but there can be a LOT of timing related problems screwing with the stereo imaging. Also, if you record in different rooms frequently, a pair of headphones you know well can give you some sort of standard reference.
If you know your headphones well, I don't see how frequency response differences between phones and speakers are really an issue - its really the same thing as learning a new pair of monitors. At least when you walk around in your room with headphones on, the bass response doesn't change. Can't really say the same for speakers in a poorly designed/treated control room. The only major problem with mixing through headphones is the fact that you can't hear stereo accurately.
Anyway, I wouldn't mix ONLY with headphones, but I think having a nice pair around as a reference is a good idea.
If you know your headphones well, I don't see how frequency response differences between phones and speakers are really an issue - its really the same thing as learning a new pair of monitors. At least when you walk around in your room with headphones on, the bass response doesn't change. Can't really say the same for speakers in a poorly designed/treated control room. The only major problem with mixing through headphones is the fact that you can't hear stereo accurately.
Anyway, I wouldn't mix ONLY with headphones, but I think having a nice pair around as a reference is a good idea.