Twins are great with pedals..... I almost sold my Twin, but at the last minute I put a Tube Screamer in front of it and it leaped to life!!
Mesa has great rhythm channel lead sound if you dime both gains.
You dont have to shatter your ears with a Twin if you put a Weber Mass on it. I leave my Twin volume and gains knobs turned up almost all the way all the time, and let the Mass stop me from breaking windows. Sounds great!