E-bow: yes. I love the thing. I would say it has taken me about 10-12 hours of combined playing time to get it past simple "sustain/feedback". On my Ibanez Artstar AS120 (ES335 copy) I have finally nailed the flute tones, it truly is sweet. Humbuckers are great, as you have a dead spot in the middle of the pickup, and a hotspot to either side.
I have been working hard at running scales with the Ebow so that I can skip across strings smoothly. It isn't easy, but I am getting there. For my style of music (okay, for one of many that I play), the Ebow is crucial for laying down gorgeous sonic backdrops. Ideally, an Ebow coupled with a Boomerang or other looping pedal would be fantastic so that you could lay down your rhythm track, and then add the ebow on top of it.