Digidesign says it's been tested with DP 4.1.2 and you are running 4.5 (presumably 4.5.2). So, technically, I guess it hasn't been tested against your version of DP or the newest MOTU release, DP 4.6. It also looks like the answer could depnd on your OS. I'm assuming your using or planing to use a Mac, since--the last time I looked--DP won't run on windows. If I read their site correctly, Digidesign has not yet released a Tiger-based standalone installer for the Digidesign CoreAudio Driver.
Are you looking for an interface to work with DP?