Dude, get the Delta 1010 It's a sweet deal for the price. 10 in 10 out,great sound and Super low latency.In NUENDO With M-Audio ASIO Drivers and my buffers set two 128, I get about 3ms in and 3ms out for a total of about 6 or 7 ms. I Only use 128 when playing through the computer into gutiar rig or if I'm tracking vocals. (I can't even here the 6ms of latency)It sounds sweet. Most times I run the buffers at 512 for about 12ms of latency. Keep in mind that I run nuendo at 24 bit and 44.100KHz so depending on your computer even lower latency is possible at let's say 32 or 24 bit but at a higher freqency like 48,88 or 96. Also I run 3 delta's together for a total of 30 ch in and 30 ch out and after about five years not one problem with this set up. hope this help's