I'm using an Athlon 64 3400+ (socket 754) with a Soltek K8AN2E-GR motherboard, two gigs of ram, a 120 gig drive for programs, and a 320 gig drive for audio (both SATA). It's been great up until now, when it's been giving me heat problems and randomly rebooting while I'm mixing or mixing down. I think it's just time to replace the CPU fan though, as I've had all the same hardware in it for almost 5 years now