I've been doing some checking, and I've also sent an email (no reply yet). My first reaction to saying "probably not" was because of the 64bit vs 32bit but I'm not 100% on that.
This site seems to show that it may be compatable;
So, I guess I'm on the other side now thinking that it might be. I've seen some other compatability matisis that give me greater concern in the way of drivers and such but that wasn't your question. If I get a reply from Cakewalk sometime soon, I'll forward it on.
My Vista version is 32-bit. I asked the guy at the store about the 64-bit and he said if I got that version I would not be able to run the majority of the programs out there.
I am trying to set up a vitual OS in my system so I can run XP.
My MOTU PCI-324 is not supported under Vista either, so I have several issues to work out.
Reason, Sound Forge, and my other Sony software seems to be working fine.