right so Ive listened to it and it sounds like its a buffer problem...thing is, and Im not judging or accusing, but you say you are using a £70 interface with £1500 software designed for post audio production? Im not saying its pirated but why use something so complicated with something so simple??
Id suggest using the GX with Reaper...its stable and simple and if you are going to record guitar based stuff its got to be more user friendly..
make sure you are using Line 6 Asio drivers as your soundcard drivers in the softwares preferences (not asio4all drivers), then adjust the buffer/latency until you get a happy medium between acceptable delay and recording quality
it doesnt sound like cables to me...also what are you playing the guitar into software wise? I thought the GX doesnt come with podfarm as a VST??