I have owned Fender, Don Grosh, and Melancon. I have played Anderson, G&L, and other strats quite a lot.
Here is how I rank my findings:
5: Fender - Great history, but now sadly a product more than an instrument.
4: Don Grosh - too expensive, especially considering the crappy bath-tub route. I don't like Don's fretwork at all. Don't like his nitro-finish either.
3: Anderson - A modern take on the strat. Awesome fretwork. Nice finishes. A little too expensive to be a good value.
2: G&L - Much more solidlly built than Fender. The tops aren't the best, but the guitars really have soul, and feel like the real deal.
1: Melancon - Again, a more modern take on the strat. Wonderful fretwork and absolutely unbeatable finishes - on par with any PRS or McNaught you can bring to the table. Hands down the best value on a hand-built strat today.
I'm a huge Melancon fan! I got mine brand new, with a Louisiana Swamp Ash body and figured Maple top for $1600 bucks! Plays like a dream, looks like a dream. You could get one without the maple top and with a standard finish for much less, and it would blow a Clapton strat out of the water, in my opinion. And just as a parting shot: I would never buy any signiture model. Sig model = overpriced.
Aaron
http://www.voodoovibe.com