take it from a software engineer
Speaking as someone who has written a number of small audio apps, there cannot possibly be a difference in the way dry audio sounds between one application and another (bugs notwithstanding) if you set the audio card's capture settings to the same values in both apps (e.g. bit depth, sample rate, preamp settings, etc.)
Once the audio has been converted to digital information by your audio card, it is a bunch of numbers, and nothing any audio app does (effects notwithstanding) will change that.
The reasons to choose one app over another are:
1. Editing ease-of-use and flexibility---does it match your workflow? Does it have the editing features you want? (e.g. time stretching/pseudo-quantization, slip & slide editing, etc.)
2. Plug-in effects---what types of plug-ins does it support, and can you get the plug-ins you want in that format?
3. Capture modes supported---does it support 24-bit or only 16? Does it record at 88.2/96kHz or only 44.1/48kHz
4. Stability.
#3 is the only way that one audio app can differ from another in terms of the quality of a dry recording. It makes a big difference if you sample at 96kHz, mainly because of low quality filters used in most audio cards. Basically, capturing at a higher rate and downsampling tends to produce less HF roll-off than capturing at a lower rate....