Yes. The difference is important. Our brains are all wired differently and we process information in different ways. If the workflow built into a DAW by the programmers matches how we process stuff, the DAW will seem to be more intuitive.
In the early years, I started with Logic, but I also tried Cakewalk and Cubase. I couldn't come to grips with either of those, and so I defaulted to Logic which I used for many years.
Despite my reluctance to switch to Reaper, when I did, I discovered the transition was way easier than expected, and I took to it like a duck to water, despite the significant differences between it and Logic. This was mainly because for me Reaper did things the way my brain said they ought to be done.
(Similarly, I've experience with Wavelab and Soundforge. For me, Soundforge seems more logical, and Wavelab doesn't make sense).