Of course you can. Just have to go through changing the input/output device in the DAW (and OS if you’ll be using it for other apps).
On a Mac you can create an aggregate device that contains both. On Windows I think the only other option would be to take the analog output from th Axe into the interface, i.e. if you didn’t want to do the switching. But, once you’ve got them set up, switching isn’t that painful.