USB vs. Firewire
Deciding what you want to do with your interface will help you choose which protocol to use. Basically, it comes down to this:
USB 1.1 - 12Mbps - generally 2 Channel devices
USB 2.0 - 480Mbps - more than two channels
Firewire 400 - 400Mbps - multiple i/o
Firewire 800 - 800Mbps - multiple i/o
Although it seems that USB 2.0 would be faster than firewire 400, this is not the case. USB 2.0 will not increase the speed of the audio at all, it only widens the bandwidth allowing more ins and outs. The audio will still transfer at 12Mbps. Think of it like this - if you are driving a car down a one lane highway at 70 MPH, and that is the fastest your car can go, adding 5 lanes to the left and right of you is not going to make your 70 MPH car go faster. It will only allow you to have 10 more cars going 70 MPH.
Firewire will actually increase the speed of transfer, and can help greatly with latency while monitoring. I would suggest investing in a firewire device. USB 2.0 is more of a sell point than anything.