You can obviously trigger in-the-box as well, you don't have to use hardware triggers. The sound of samples is great for rock and metal stuff, but use sparingly in funk etc., maybe to get consistency on accents or something.
The best drum sound I've found is using a close-miked kit, triggering kick, toms, and snare accents (which you do by setting a high volume threshold), and mixing it with the live mix.
I sampled single hits of the drums, recorded immediately before the take; this gives a much organic sound IMO than reason or whatever built-in sounds.