Are you talking about the Digi001?? It's compatible with AMD, the question is whether it gets along well with your motherboard...
Find out what chipset your motherboard uses (Via kt266a, Amd 760 or Amd 761, Sis735 or Sis 745, nforce 420....just some chipsets of the top off my head) and do a search on the DUC (Digidesign User Conference, it's just a silly name for their forums), to see if there's any known problems.