like most things, it depends...
hardware / software conflicts pop up all the time. The easiest thing to do is ask about a particular combination, or try searching about it. Some things don't like hyperthreading, or VIA chipsets, or other such things...
I don't think it's a 'new computers are more prone to problems' issue, just 'different parts don't always play nice', regardless of new vs. old.
anyway, just another 2¢