AlexW said:
If your converters are pristine and you have a good quality mixer the benefit could certainly outweigh the loss in conversion.
I agree completly with that at its face value, but I'd also say that of the people that frequent this forum, we'd be lucky to find 5-10% of them who have anything close to "pristine" converters. That would include me. I use a MOTU 2408 myself, which is not a bad device (I rather like it actually), but I wouldn't even dare to set it next to something like an Apogee or a 2192. And, as much as I like my 2408 (or a Firepod or a Tascam 1804 etc.), I wouldn't want to run my sound through them any more than is necessary.
That said, I *do* do just that on occasion; sometimes to take advantage of
my Pro VLA when the mix really calls for it (no snickers, please, I'll take that box with matched, quality tubes over a "toob" or "opto" plugin any day of the week

) or a great piece of analog gear that someone mught bring over, etc. But even in those cases, I'll try to loop the process direct and bypass my mixer, if possible.
And the origin of this thread was asking about using an analog mixer for
mixing. I ask, semi-rhetorically, is it worth the cost of signal length and integrity to go out to something like a Mackie (which I also own) or a Spirit or an Alesis mixer? To what advantage? Are they, by themselves, going to make the signal sound any better? It's not like they add any "analog warmth" that's worthwhile or that their EQ sections are worth writing home about or anything. No, I say they are, at best, going to have minimal effect on the sound, though any minimal effect will be negative and not positive. At worst they will drape a veil of coloration and dynamics loss over the sound that was not there at the inputs.And THAT is much to high of a cost to pay (for my audio budget, anyway

).
Give me a rack of Apogees and some nice Rupert Neve channel strips and I might go out to analog all day from my DAW and back again. But otherwise, once it's in there, keep it in there unless you have gold on the outside.
Again, that's just one point of view. Everyone is welcome to disagree...many usually do

That's what forums are for!
G.