My own personal recipe:
1. Strat w/rosewood neck for warmer tone;
2. 1961 Rickenbacher combo amp (same tubing as a vintage Tweed) with the original Jensen blue label 10" speaker; and, most importantly,
3. Soul.
On occasion, I also use a Roland GS-6 as a preamp and for chorus/delay effects. The 6V6 tubing of the Rickenbacher adds a lot of warmth to the somewhat sterile digital signal output of the GS-6. I tend to favor sounds produced using fingers, pick attack, picking at various spots up and down the guitar, etc. over use of effects pedals.
Most important, *less is more* when playing the blues. If what you play doesn't sing and cry and make the listener do the same, it's just musical masturbation.
Best regards from Texas,
Tio Ed