Well, what have you actually done so far? Re-reading your post, the impression I'm getting is that you haven't really tried anything yet.
You read the manual? I'm looking at it right now. After the obligatory "Overview", the next thing it says is the following:
<<<<Hardware Installation
Installing your Radium involves simply attaching it to your USB port using the
standard USB cable that is included. We recommend that you power down
(turn off) your computer for a first time installation. If you are using the Radium
in USB mode, a power supply is not required.The computer’s USB port provides
the power to run the Radium.The “wall-wart” supply is only necessary for use
in the standalone mode.However, when the Radium receives its power from the
USB port,we recommend either plugging directly into the computer’s USB port
(not into the keyboard’s port or a powered USB hub).>>>>
So that answers your first question.
Referring to the "Setting Up Your MIDI Studio" section now-
<<<<Setting Up Your MIDI Studio
A typical MIDI system set-up would include your Radium, a computer, MIDI
sequencing software and/or a MIDI compatible sound module. This type of
set-up can be connected as follows:
1. The Radium is connected to the computer via the USB port connectors,
using the supplied USB standard cable.
2. The Radium can play the synthesizer that is part of an internal sound card,
as well as any software synthesizers that are installed in your system.This will
depend on how you set up your software (see the section “Using the Radium
in Your Application Software”). The audio output of the sound card can be
plugged directly into a sound system, or into a mixer, which is then
connected to a sound system.
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3. The MIDI Output of the Radium is connected to the MIDI In of a sound
module. The audio output of the sound module can be plugged directly into
a sound system, or into a mixer, which is then connected to a sound system.
In the setup pictured below, the Radium is being used as a MIDI controller as
well as a MIDI interface, inputting MIDI data to the computer and its application
software, and outputting MIDI to a sound module from which sounds will be
produced. The Radium as a controller may also send MIDI information to an
existing internal soundcard’s MIDI synthesizer or any installed software
synthesizer, outputting the audio from the computer soundcard.>>>>
Answer 2.
The Radium 61 is pretty straightforward. What have you done so far?
Ted